徐成 博士

副研究员、入选楚天学者计划

教育经历

2010 — 2016 日本东京医科齿科大学骨外科博士

2007 ­— 2009东北大学生物化工 硕士

2003 ­— 2007东北大学生物工程 学士

工作经历

2019 — 至今江汉大学系统生物学研究院 副研究员

2017 — 2019美国康奈尔大学附属医院纽约特种外科医院 (骨科全美第1)博士后

2016 — 2017美国宾夕法尼亚大学 牙医学院 访问学者

研究方向

主要利用基因敲除小鼠模式生物，运用遗传学、细胞生物学、分子生物学等方法致力于以下相关研究：

1. 细胞器（纤毛、线粒体和细胞蛇）发生与骨骼退行性疾病中的分子机制；

2. 神经以及脂肪等体系在骨重建中的作用机制；

科研成果

1. Cheng Xu^#, Gregory J. Vitone^#, Kazuki Inoue, Courtney Ng, and Baohong Zhao^*. Identification of a novel role for Foxo3 isoform2 in osteoclastic inhibition.J Immunol. 2019, 203(8):2141-2149. (被该杂志亮点推荐DOI: https://doi.org/10.4049/jimmunol.1990018)

2. Shinichi Nakano^#, Kazuki Inoue^#, Cheng Xu, Zhonghao Deng, Viktoriya Syrovatkina, GregoryVitone, LiangZhao, Xin-Yun Huang & BaohongZhao^*. G-protein Gα13 functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function. Sci Rep. 2019, 12;9(1):4236.  

3. Takeshi Takarada^#*, Cheng Xu^#, Hiroki Ochi, Ryota Nakazato, Daisuke Yamada, Saki Nakamura, Ayumi Kodama, Shigeki Shimba, Michihiro Mieda, Kazuya Fukasawa, Kakeru Ozaki, Takashi Iezaki, Koichi Fujikawa, Yukio Yoneda, Rika Numano, Akiko Hida, Hajime Tei, Shu Takeda, Eiichi Hinoi^*. Bone resorption is regulated by circadian clock in osteoblasts.J Bone Miner Res, 2017, 32(4):872-881.

4. Cheng Xu^#, Hiroki Ochi, Toru Fukuda, Satoko Sunamura, Shingo Sato, Takeshi Takarada, Eiichi Hinoi, AtsushiOkawa and Shu Takeda^*. Cricadian clock regulates bone resorption in mice. J Bone Miner Res, 2016, 31(7):1344-55.

5. Chengshan Ma^#, Toru Fukuda, Hiroki Ochi, Satoko Sunamura, Cheng Xu, Ren Xu, AtsushiOkawa and Shu Takeda^*.Genetic determination of the cellular basis of the ghrelin-dependent bone remodeling. Molecular Metabolism, 2015, 4(3): 175–185.

6. Takeshi Takarada^#, Eiichi Hinoi, Ryota Nakazato, Hiroki Ochi, Cheng Xu, Azusa Tsuchikane, Shu Takeda, Gerard Karsenty, Takaya Abe, Hiroshi Kiyonari and Yukio Yoneda^*. An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res, 2013, 28(10): 2064-9.

7. Toru Fukuda^#, Shu Takeda^#*, Ren Xu^#, Hiroki Ochi, Satoko Sunamura, Tsuyoshi Sato, Shinsuke Shibata, Yutaka Yoshida, Zirong Gu, Ayako Kimura, Chengshan Ma, Cheng Xu, Waka Bando, Koji Fujita, Kenichi Shinomiya, Takashi Hirai, Yoshinori Asou, Mitsuhiro Enomoto, Hideyuki Okano, Atsushi Okawa & Hiroshi Itoh. Sema3A regulates bone-mass accrual through sensory innervations. Nature, 2013, 497(7450): 490-3.

   联系方式

   E-mail：xucheng_2007@jhun.edu.cnorxucheng_2007@163.com